Science and Technology

Overview

LDS’s proprietary platform technology enables the embedment of large loads of active molecules, including poorly permeable, soluble or non-soluble active molecules, on the liquid nano-domains. The nano-structures are used in the pharmaceutical, nutraceutical, and cosmeceutical industries. The flexible nano-structures consist of lipid-based ingredients loaded with membrane recognition, permeation agents, and the active molecules on their interface or core. The unique technology consists of homogeneous nano-structures with a maximum size of 50nm, forming transparent fluids. The nano-structures are inexpensive to manufacture (simple scale-up), requiring almost no energy input or unique equipment, and can be made at any temperature. The nano-domains are physically extremely stable, with a long shelf life, and can be stored either as liquids or in powder form to be further used as creams, tablets, sprays, films, gels, and more. Unlike solid nano-particles that are not recommended by regulatory authorities (including the FDA and EMA) because of their involvement in cell apoptosis, LDS’s nano-domains are liquids and are considered safe and non-toxic.

We use the most sophisticated and advanced equipment


We have access to state-of-the-art analytical tools in our own laboratories or in the Nano-Center at the Hebrew University, which allows us to characterize and to understand the nano-domain structures and properties profoundly, both in the development stages and after production.

Unique structure that enhances delivery

The core technology at LDS is derived from new molecular engineering models that allow the formation of new types of modified nano-domains. The domains are “coronated” in their interface with membrane recognition molecules and permeation agents facilitating the active molecule’s efficient transport.
The structures enable intimate contact with the target tissue surfaces, facilitating the diffusion of the active molecule across the membrane. Furthermore, the structures include components that allow the delivery of the active molecule to the surfaces or the membrane’s interface without any intermediary.

Controlled release at the required rate


LDS carefully selects the proper ingredients to allow each nano-domain to solubilize a specific active molecule at a required loading capacity. The nature of the active molecule and its embedding on the interface of the nano-domains (and not in their core) can be manipulated to achieve controlled release.
We customize the active molecule release using few proprietary nano-structures that work together to optimize the active molecule solubility and deliverability and the order of the structure.

How does it work?

The tailor-made ‘oily’ nano-domains are designed and prepared by loading the active molecules at the interface or core of the structures. The domains are coronated with several excipients facilitating the permeation of the active molecules across surfaces, or membranes (‘permeating agents’). Only once the nano-domains migrate to the interface and recognize the delivery site will the structure adhere to the surface and allow the active molecule to be released by diffusion.
The delivery is processed in four main steps:


Migration of the nano-domains to the membrane

The nano-domains recognize the specific membrane surface onto which they will adhere.


The nano-domains adhere to the membrane

The nano-domains adheres to the membrane and the active molecule is released by membrane undulation.


Active molecules permeate the membrane

The nano-domains’ intimate contact with the membrane allows passive diffusion of the active molecules.


The nano-domains depart from the membrane

The empty vehicles depart from the adsorbing site and are discharged from the body.

Publications

Potentiality of micro-emulsion systems in treatment of ophthalmic disorders: Keratoconus and dry eye syndrome - In vivo study
Nina Lidich Sharon Garti; Levy Abraham Aserin, Nissim Garti. Colloids Surfaces B, Biointerfaces 2019, 173:226-232, 2018.
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Patents

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orta at purus id scelerisque. Pellentesque ut ante pulvinar, tincidunt arcu quis, pulvinar leo. Nunc dapibus porttitor nulla id aliquam. Donec at euismod odio, at faucibus augue. Ut molestie mi sit amet mi
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orta at purus id scelerisque. Pellentesque ut ante pulvinar, tincidunt arcu quis, pulvinar leo. Nunc dapibus porttitor nulla id aliquam. Donec at euismod odio, at faucibus augue. Ut molestie mi sit amet mi